Insulin-like growth factor binding protein 2 expression and prognosis of glioma patients: a systematic review and meta-analysis
نویسندگان
چکیده
Many studies have focused on the prognosis role of insulin-like growth factor binding protein 2 (IGFBP2) in glioma patients, but the results remain inconsistent. Thus, a meta-analysis was carried out to explore the relationship between IGFBP2 and glioma prognosis. Relevant publications were searched in several widely used databases and six articles (seven studies, 766 patients in all) were included in the meta-analysis. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between IGFBP2 and glioma prognosis. Significant relationship between IGFBP2 expression and glioma prognosis was not observed in overall meta-analysis for overall survival (HR = 1.044, 95% CI = 0.998-1.093). However, increased IGFBP2 expression is significantly associated with poor overall survival in the multivariate analysis subgroup (HR = 1.036, 95% CI = 1.024-1.047) and glioblastoma multiform subgroup (HR = 1.028, 95% CI = 1.003-1.054). According to the results of our meta-analysis, higher IGFBP2 expression in glioma patients is associated with unfavorable prognosis and has predictive effect on overall survival for glioma patients, especially glioblastoma multiform patients.
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